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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5eeddcdb6c4dc8c88a255786979bc6fabf9717e4dc682949ab3feb5b0eb67301' 
  AND token = 'xEMy24LEVPmGlrilIDz3n1+Ndh250HeyB1DscyHZ3Dw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}