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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59e5ba1d3cc09b3c3d1bbb1f4f306548294503d781a56193bfab756554dd3f04' 
  AND token = 'IZx16tiOU+G2gMjQ1V6HvE0V9A3gnu0vo/RXgxWw1bg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}