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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49106614c68edae4c8c74878c9567b57559ce477bbbddcf2cdfe00d21d97b66a' 
  AND token = 'Uh3MkCXEtQ/FNKzW+BLdUn6Hn4xI4bZ47RsGOvgaVPA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}