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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '294441fff63786d4e1646a94d7c27340bd99666f3d30abd4296f9bd8802a134f' 
  AND token = 'x/OkD5PbKnQ90Xm+b8i7Y/dr+q2yWRiUXR5mRpf9qso=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}