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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18c08d99ca9c70b31ca9c36646bcebb59d365f79d9e5e3f80d96853201506978' 
  AND token = 'SIBAx1MORZTKv3ijBo7ijdLQoi+MkGlVAn7mv38B19c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}