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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '01450c728f78080567013a1fe29e43ef1a3994c100c78d2a4bf0458e4f8ca722' 
  AND token = 'G7J/kdaS81wxf2AosYTKT3/velmFLoSyoCBLatrMqaI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}