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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd722bed202cf4aac43162e69f5028963a9070c8cf6688bbbcc55e866ce675a3d' 
  AND token = 'U2yOeHJHS3NrcdDqR6tiM0P8tZCpDCbksbiDbvyP5aY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}