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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '00653fc49e5d0276d9864f1c528bb346835e720e319e85a96eda7305d8c85cde' 
  AND token = 'Rv4X2NdoJatcjnrkTqYOb6rVoynXp7cZutXgGsmECoE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}