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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '20d226c4d0690b9fe4d915544e267d06b5e4136e2cf6a440fabde71f4f1f47b4' 
  AND token = 'sxZqePoDAzEL0WpT978+miDpKQs+7obUKKKv75OHcHU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}