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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '19a2e037664e63d9e2e44ef13481aa228a71c7e2470238d51a750d23f21b8dbf' 
  AND token = 'Ua7+JkwaNeLI5I8e4XTJPn8icjJNn0AAe6aqBLN/Aw0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}