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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9de564cab449ff6c664871996c3891e2c309a421806f7abb86e3678e2a80be84' 
  AND token = 'sz03OGfpCgBwKkWiRwSlXp0plA2BCPe7p0bZlDrVlE8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}