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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e0c306f02868d4291a4145f095fcf81d3364075c2351f9c2d14800517acc2a5' 
  AND token = 'TKY6wLNx91y1ZCwA5fS/WkSTg1KWBywRkX1BRJ1q7h8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}