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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0b8ae224d949e6559d458045997c82ca656679a78b448586ccea666818a969c2' 
  AND token = 'TzuVPnO1PKS4sUBVFyHyn4G1nORMdtXU/IvVJmFUoLc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}