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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48250b0d0f2a3ae8ab68035269164ae43b8c47c91d6684a06868f82a426757d1' 
  AND token = 'XDZA3pm1bijx0vhzcN9EaY0EyH6+pJqYh1UoRJA36e8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}