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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10ff56099b13605e813e25682bdb9d842b3b246f724b22b67dfc0ae23b5e5ca4' 
  AND token = 'rUMFWTCyXjmkaT/Aasp1TsJCFGJpOYkwc8z6OlmJBBo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}