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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b06deb0cceb040746429a9be5f054b2cec31b89b0d196ab611c5da4174ac9b4' 
  AND token = '5lOlhyuNTU78dtYUtZ3EaY+ms9LNcjAQpW8GxgMIYRU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}