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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b743ac8982c13a72dccaadc2315bfefb08c21410fb8f3558bb597667a1b7539a' 
  AND token = 'BdPBb3QBCWvDFwajzNu8JtjeFBMt07nqiJLd0frihcg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}