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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '166e8f7e0915761ea4ff5005b3468e9f7683a9da2e7f3d024957eb0fd54e6f76' 
  AND token = 'TguyiYNimPc2QckvfwpZDDgLqbCwPPlvOLdM1qSlKlo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}