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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21147a0423121d035b3f1acfba59a6f00b1ceab946b9bdb955aa945d3c6c95ab' 
  AND token = '3AZi/9p0aChPXb9VFwj+kcR9I3RwS5W9GOLUSeTQwoQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}