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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '66d49224e1751b5971d4a269e6e06c408631c4911084891ecf4ebf2773fa3528' 
  AND token = 'SaFnrIJRxjuxmYFoh2js/gR5qSk9s4MEyTKhLIKp6gg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}