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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1c33cb1eebee5b3860db678d9a3d3fa771993047b9b01450d61a4fe257a4b502' 
  AND token = 'VXsyo2baU3CgR709kNgU8LmEAcscbghO2OYnF4KJ9ro=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}