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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '408df899fb50d2c708909706a75af1b0aa4122afe1b277a50b9b267011a5f9c1' 
  AND token = 'JDS7iAQHfec4GG3TFbf9GhExeH1VeIyqy0r4ikZKZVA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}