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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4372717989aaaa3843e504194ef0a0a0285df7d0816f8f0321e7d9dc1c82e553' 
  AND token = 'xJDPE1uKxc50cpGc42DFOtn6v3q3TMn6/SxsfVtR2ZA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}