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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5d0c474f224c85e1c5f8291e679e65b6fbf1667d1d6048b5601689a1822dcf48' 
  AND token = '0Mc7xOSADG4ckQHZ4ml8bmI4HY0LP2sFe+SaUCS2KGg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}