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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '66ceb4a38a7a03a8f7fe29a95faabd8b916ac992e229dabb0551d970a3731885' 
  AND token = 'B1W4QL2svFdUHS7IUdqAj+5Di3VX/FCCfI7VH9Wyd/0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}