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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e05d9c5f67875297555b5b727af807851b85a2bdb6a9520ba346677014f5c456' 
  AND token = 'xOaBrlCzKD4+L39B90jOoxWMNyLW49cUWuttKZA4GRQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}