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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6c378394f44daaf82059c02d621b2f5118661f27361ec31c664a2c5713b2359b' 
  AND token = 'GzsEqb9mLDPqPiAqpGsl823nMyZe7hiRllOFIJ0xM7U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}