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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0461445ca052f67154b271c2195f0e11da0de0b4eec452b55c9bb49b7f718534' 
  AND token = 'Dgb0CvDr2FwcSUAsMf61RF3LbHAEgT1ImLRmPMDTQ1g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}