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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22acc16fbb53533e6d6b00b4265e8c750db188c2acfffee36fb71a8255a4d394' 
  AND token = 'o6ReCxJ3jiXstKRf+qbXJgWs1r9uKS9E/YbUr5l5+sU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}