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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9f0bf00306f26883df8f3e0afcf9d68f917b00f74ddda27e1537ebb060973057' 
  AND token = 'ZQT7IyHSA0jz/9Kks/YfQOPoWj3XUr9Faamn/Qj3NrI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}