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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '485bda78f37c87a6795f498fd838ed486c32614f7d0d0b8e31d1e76a51415210' 
  AND token = 'fsG21/XcXVnEVW6q6kbu1ODEYxDxSvdQynEWEX3u4aw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}