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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50e80ca381dac0dce345eb38e1d744eb56836f846826cc17d55a40d04e6d3cdf' 
  AND token = 'bVskwc43pR3RNLt2h2WADY0lsxPaGd3iPT02+OwN2SI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}