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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '37222def379ad579ec8f74282b64e064894cb44f67c9c5f0f2d13a5af4bab3bc' 
  AND token = 'hcjMJdoIvZGL/kmGrjVqeOrMdirv4B4PtMj2ktxh7GE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}