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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78e6e1c1ea1ba05a997437a9541d0528a40362eafdc3e57133c51dc0cbae72a8' 
  AND token = 'DQMG0aRxe3iWQDhdcegUSfhFEL6WeEPep4Q0q32JMPc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}