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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42b5f0faa2956fe765b5415de15e6becc633c03b823a1fbf62c2f1544ce6f8f0' 
  AND token = 'I4+OeXlJ0DVGSmrYRMhwVxo2nVuKFHjOVIzO13EbPjk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}