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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5254cc4f34c647b6da1772ea09bec39a4ee390e75fd61d30d99ca8f06b9a0f48' 
  AND token = 'qQGyFB69xxR0o5D31r3CPmtJXr3ffUTOOi/fDxMPqW8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}