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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4499ded6041b95dffcfef0d483d13890e2497d23b8be27d6218b4c4f80851c8e' 
  AND token = '1ESTu8M8+FwlCPp8uLZ/nIxnoz63RA2WsvxU6Ysp9GI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}