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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e462a0a50ea87248ce461f87b6ca29dcb4380ceebfb3e196c48c71e567727aef' 
  AND token = 'NdNehpB76Xpncwg7zVM9TAbq29irOZEQPTtMxpIxPn8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}