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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8a2aa73895dc7c01a356f8d945c5c9d56c5802d8382363b5b1cb564a647e066f' 
  AND token = 'Zku7wEBOgGULCUu1C+3Rvao/Ub2EF1Noy2CdnpaXkM4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}