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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '527895363e08a64c6451b11c7a363ad6ed6759e1871f68da58a6e7d298e0b6d2' 
  AND token = 'IQQrU3JVI+7eKwwWZAohSLFV9LN3fKPpYJblfTkNpoM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}