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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '488d2cc1e2edadb72d1ce6dd309ac66bdf4cfb66a7b595daf3d5f938f35f2384' 
  AND token = 'UsxrMTyvBxSxeLYVePt+EZwY8+4uTtUMpiwpbWisY2Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}