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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22ce5230b3e66b7c5d096d0161cc1d46a88391fb288c43489f3e667f9dff4c99' 
  AND token = 'Cq2813xzjdUwxbC1+6dmC7y37BqDcc2DhF9Sc5m6Rx4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}