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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd621d61641e13829252525a55d4f1d876227fa321f09378570b149a5ac3656c4' 
  AND token = 'eugO4saA6AVlvhxpQE6487IeCdmqV10QQaT9SyJYjGQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}