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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed5279800f898ab3a599a34cde1692ad43476d479f942edb4acbd61e740ef4d8' 
  AND token = 'rSQNnAp7oqE1aGEg3v3cHKclyN2k4Ipw67cFEi2EsfA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}