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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de35d75e7d47886225b286a8e6075b8a46bb8fc9f3279ce61a09c0678c586cfc' 
  AND token = 'e+fgVQNRP66Gn3MrxSMZKQUUh7CBMuVoDS5O4XhcOlU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}