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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de6fac6c04202c415132be10187012fff71d07eddd3cb1c9eb69793176b7763c' 
  AND token = 'VXFdZlrDT1BM1UYPzv8/CVM4WW5u+oCtCGPQaZGPV4c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}