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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c5acd8ff51591ff4d258566aed62f52c030f011f13b177d1b286c48b9e7c5bc' 
  AND token = 'ZfiSAfQkpNPY/mcn66tPVJRdF9Qo8sCImPYk9qzY6mw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}