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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '347b0e88157aed6303a9b40a96eba44f9c8c54d2572e84859889e05d807ad4b3' 
  AND token = 'p9a1YKoo9JtXF86qm0bM6HgrEXitLXL4QsvwPFnrES0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}