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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd45368c3dc2bd6ce23d3ed1ad04a3eac0af8ac2329d2afef8c30c889a5025615' 
  AND token = '22XhAdNyd2Pjti9yb8rnAJ/iGoqB5Fs08nhx7qv8EKY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}