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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12d5f8623980e4b97dbd8236b3523e4a83b6c50f778dd0cb1497ba5b3d5b6231' 
  AND token = 'vM8Hdbub5FuLN/aJywSYIQv+OnvG9Gipl8cEbbLAJvs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}